Generic Uni-dur

Uni-dur Effects and Usage

Uni-dur - Pliva's Generic Version

What kind of medication is Uni-dur?

Uni-dur is a brand name of theophylline. The medication has bronchodilator properties used to treat symptoms of difficulty breathing caused by respiratory diseases such as asthma, chronic bronchitis, or emphysema. Uni-dur works by relaxing bronchial smooth muscle that surrounds the bronchial tubes of the lungs, thus widening air passages in the lungs and making breathing easier. It also improves contraction of the diaphragm.

Pliva Pharmaceuticals, Inc. manufactures a generic version of Uni-dur available as Pliva 482 200 mg and Pliva 459 300 mg pills.

The medication is also marketed under other trade names that include: Nuelin, Quibron-T, Slo-Bid, Theolair, Theox, Theo-24, and Uniphyl.

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What are possible side effects of using Uni-dur?

Adverse reactions may include:

  • nausea
  • diarrhea
  • stomach pain
  • headache
  • dizziness
  • fast or irregular heartbeat
  • insomnia
  • restlessness
  • irritability
  • If overdosed, Uni-dur may cause seizures, vomiting or skin rash.

    Unwanted effects of Uni-dur can be increased if it is combined with other medications. They can also be increased when Uni-dur is taken with fatty meals, which may result in the so called dose dumping (premature and exaggerated release of the drug).

    What is the recommended dose of Uni-dur?

    The total daily dose may be calculated on the basis of 10 to 15 mg per 1 kilo of body weight. The total dose is divided into 2 to 4 equal parts taken regularly during the day. However, due to the fact that high amounts of Uni-dur can be toxic, and the level of the medication in blood can be affected by many concomittant factors, the optimal dose should rather be determined by the physician who will monitor the level of the drug in your blood during several days or even weeks regularly.

    When should Uni-dur be avoided?

    Uni-dur should not be used

  • in patients allergic to Uni-dur, similar medicines (e.g., aminophylline), or xanthines (e.g., caffeine, chocolate)

  • Uni-dur should be used with caution

  • by pregnant or breast-feeding women
  • by patients who have a history of heart problems
  • by patients who have a history of liver problems
  • by patients who have a history of ulcers
  • by patients who suffer from seizures and / or nerve problems
  • by patients who suffer from fluid in the lungs
  • by patients who suffer from severe infection, including viral infection and blood infection
  • by patients who suffer from scystic fibrosis
  • by patients who have increased acid levels in the body
  • by patients with thyroid problems
  • by patients who smoke
  • by patients who consume large amounts of products containing caffeine (such as coffee, cocoa and chocolate)

  • Uni-dur should not be combined with:

  • Aminoglutethimide (Cytadren), barbiturates (such as phenobarbital (Luminal)), beta-blockers (such as propranolol, (Inderal, Innopran XL)), carbamazepine (Tegretol), hydantoins (such as phenytoin (Dilantin)), isoproterenol, moricizine (Ethmozine), propafenone (Rythmol), rifampin (Rifadin), St. John's wort, or sulfinpyrazone (Anturane) because they may decrease Uni-dur's effectiveness

  • Allopurinol (Zuloprim), cimetidine (Tagamet), disulfiram (Antabuse), enoxacin (Penetrex), estrogen, fluvoxamine (Luvox), interferon alpha-a, macrolide antibiotics (such as clarithromycin (Biaxin) or erythromycin), methotrexate (Trexall), mexiletine (Mexitil), oral contraceptives, pentoxifylline (Trental), quinolone antibiotics (such as ciprofloxacin (Cipro)), tacrine (Cognex), thiabendazole (Mintezol), ticlopidine (Ticlid), troleandomycin (Tao), verapamil (Verelan, Covera-HS), viloxazine (Vivalan), or zileuton (Zyflo) because of the higher risk of worsening Uni-dur's side effects

  • Ephedrine because the risk of side effects such as nausea, nervousness, and trouble sleeping may be increased

  • Halothane because of the higher risk of irregular heartbeat

  • Ketamine because of the higher risk of seizures

  • Adenosine (ATP), benzodiazepines (such as diazepam (Valium), lorazepam (Ativan), clonazepam (Klonopin) or alprazolam (Xanax)), dipyridamole IV (Persantine), lithium, midazolam, or nondepolarizing muscle relaxants (such as pancuronium (Pavulon)) because their effectiveness may be decreased by Uni-dur