Trazodone Hydrochloride


Trazodone HCl Effects and Usage




Trazodone HCl - generic Desyrel

What kind of medication is Trazodone HCl?

Trazodone hydrochloride is an antidepressant medication with anxiolytic and hypnotic properties. It is mainly used to treat depression, but may also be used as an anti-anxiety medication (relieving sleeplessness and tension) and as a reliver for chronic pain.

When distributed by Pliva Pharmaceuticals Inc., Trazodone HCl is available on the market as Pliva 433 50 mg Pliva 434 100 mg and Pliva 441 150 mg pills.

The medication is also marketed under the trade name Desyrel.

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What are possible side effects of using Trazodone HCl?

Possible adverse reactions include:

  • drowsiness
  • dry mouth
  • nausea and/or vomiting
  • headache
  • tremor
  • irregular heartbeat
  • dizziness
  • fatigue
  • confusion
  • memory loss

  • What is the recommended dose of Trazodone HCl?

  • In adults, the initial dose of Trazodone is 75 mg taken twice a day. The doses may be increased by 25 mg every three to four days. The normal maximum dose should not exceed 200 mg taken twice daily. Severely depressed patients may be given up to 200 mg three times a day.

  • In children, Trazodone is usually not recommended. If required, the dose must be determined by the doctor.
  • The medication should be taken after having a meal.


    When should Trazodone HCl be avoided?

    Trazodone HCl should not be used

  • in patients allergic to Trazodone hydrochloride

  • Trazodone HCl should be used with caution in:

  • pregnant women and breast-feeding mothers
  • patients with a history of drug abuse or suicidal thoughts
  • patients with schizophrenia, or other psychiatric illness
  • patients with heart problems

  • Combining Trazodone HCl with other medications.

    Trazodone should be taken with caution in combination with:

  • an HIV medicine (e.g., indinavir (Crixivan) or ritonavir (Norvir))

  • antifungal medications (e.g., ketoconazole (Nizoral) or itraconazole (Sporanox))

  • digoxin (Lanoxin, Lanoxicaps)

  • seizure medicine such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin)

  • warfarin (Coumadin)

  • MAOIs (e.g., isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate)) within the past 14 days of using any of them last

  • An overdose of Trazodone can be fatal if it is combined with alcohol, barbiturates (e.g., phenobarbital (Luminal)), or sedatives such as diazepam (Valium).