Propranolol Hydrochloride

Propranolol HCl Effects and Usage

Propranolol HCl - generic Periactin

What kind of medication is Propranolol HCl?

Propranolol hydrochloride is a non-selective beta blocker mainly used to treat hypertension, angina (chest pain), heart rhythm disorders, and other cardiovascular disorders. It works by blocking the action of nerves which stimulate the heart rate. It also lessens the force of heart contraction.

Due to the fact that Propranolol has a sedative action on the nervous system, it is sometimes administered as an anti-anxiety agent. Other uses for Propranolol include preventing of migraine headaches and the treatment of certain types of tremors.

The medication may be marketed under various trade names, too, including Inderal and InnoPran XL.

When distributed by Pliva Pharmaceuticals, generic Propranolol is available on the market as Pliva 467 10 mg, Pliva 468 20 mg, Pliva 469 40 mg, Pliva 470 60 mg and Pliva 471 80 mg pills.

Generic versions of Propranolol HCl are marketed by other manufacturers, too, including Mylan Pharmaceuticals. See Mylan's Propranolol.

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What are possible side effects of using Propranolol HCl?

Propranolol is reported to be generally well-tolerated. Rare or mild adverse reactions include:

  • nausea
  • abdominal cramps
  • blurred vision
  • decreased concentration
  • insomnia
  • hallucinations
  • nervousness or excitement
  • fatigue
  • slow heart rate
  • erectile dysfunction

  • What is the recommended dose of Propranolol HCl?

  • In children, the total initial daily dose may be calculated on the basis of 0.5 mg per 1 kg of body weight (about 0.2 mg per 1 lb). The maximum daily dose should not exceed 8 mg per 1 kg (about 3.5 mg per 1 lb) of body weight.

  • In adults, the minimum sufficient daily dose is 20 mg, while the maximum dose should not exceed 320 mg daily. For hypertension and migraine prophylaxis, the usual starting dose is 40 mg two times a day, with the usual effective dose ranging from 160 to 240 mg daily. For tachyarrhythmia, anxiety and hyperthyroidism, the dose is 10 to 40 mg three to four times a day.
  • The drug is taken before meals or at bedtime.

    When should Propranolol HCl be avoided?

    Propranolol HCl should not be used

  • in patients who have asthma
  • in patients with 2nd and 3rd degree heart block or uncontrolled congestive heart failure
  • in patients with bradycardia (less than 60 heart beats a minute)
  • in patients with severe hypotension
  • in patients allergic to Propranolol hydrochloride
  • while drinking alcohol

  • Propranolol HCl should be used with caution in patients with:

  • bronchitis, emphysema, or other breathing disorders
  • diabetes
  • low blood pressure
  • a heart block
  • liver or kidney disease
  • depression
  • myasthenia gravis (a muscle disorder)

  • Combining Propranolol HCl with other medications.

    Propranolol may cause unwanted reactions if combined with:

  • clonidine (Catapres)

  • digitalis (Lanoxin)

  • dobutamine (Dobutrex)

  • haloperidol (Haldol)

  • isoproterenol (Isuprel)

  • blood thinners (e.g., warfarin (Coumadin))

  • antidepressants (e.g., amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil))

  • MAOIs (e.g., isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate))

  • aspirin and other non-steroidal anti-inflammatory drugs (e.g., ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis))

  • doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin)

  • other heart medications (e.g., nifedipine (Procardia, Adalat), reserpine (Serpasil), diltiazem (Cartia, Cardizem), or verapamil (Calan, Verelan, Isoptin))

  • amiodarone (Cordarone, Pacerone), propafenone (Rythmol), quinidine (Quinaglute, Quinidex, Quin-Release)

  • ACE inhibitors (e.g., benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik)