Pliva's Metronidazole

Metronidazole Effects and Usage

Metronidazole - generic Flagyl

What kind of medication is Metronidazole?

Metronidazole is an antibacterial drug used to treat certain vaginal and urinary tract infections, amebic dysentery and liver abscess, and other infections caused by certain bacteria.

Metronidazole is available on the market as Pliva 333 250 mg and Pliva 334 500 mg pills distributed by Pliva, Inc. (former Barr Laboratories).

The medication is also marketed under trade name Flagyl.

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What are possible side effects of using Metronidazole?

Adverse reactions are rare, but they may include:

  • abdominal cramps
  • diarrhea
  • confusion
  • constipation
  • headache
  • nausea
  • loss of appetite

  • What is the recommended dose of Metronidazole?

  • In pediatric children suffering from amebic dysentery, the dose may be calculated on the basis of 35 to 50 mg per 1 kg (about 2.2 pounds) of body weight. The total daily dose is normally divided into three equal parts. The treatment lasts 10 days.

  • In adults, the recommended dose depends on the variety of infection.
  • In case of trichomoniasis, either 2000 mg of Metronidazole, taken as a single dose or divided into two equal doses taken in the same day, or 250 mg taken three times a day during a week.

  • In case of amebic dysentery, 750 mg taken three times a day during 5 to 10 days.

  • In case of amebic liver abscess, 500 to 750 mg taken three times a day during 5 to 10 days.

  • In case of anaerobic bacterial infections, the dose may be calculated on the basis of 7.5 per 1 kg (about 2.2 pounds) of body weight taken every six hours.

  • When should Metronidazole be avoided?

    Metronidazole should not be used

  • in patients allergic to Metronidazole and/or other nitroimidazoles
  • in pregnant women during the first 3 months of pregnancy
  • while drinking alcohol, or taking medicines that contain alcohol
  • in patients who have taken disulfiram (Antabuse) within the past 2 weeks

  • Metronidazole should be used with caution in patients with:

  • nerve, brain, or blood problems
  • Crohn disease
  • a history of liver problems or seizures

  • Metronidazole should not be be combined with:

  • Disulfiram (Antabuse) because of the risk of severe mental or mood changes

  • Amiodarone (Cordarone) because of the risk of irregular heartbeat

  • Barbiturates (e.g., phenobarbital) or phenytoin (Dilantin) because they may decrease Metronidazole's effectiveness

  • Anticoagulants (such as warfarin (Coumadin), etc), busulfan (Busuflex, Myleran), cyclosporine, ergot alkaloids (e.g., ergotamine), HIV protease inhibitors that contain alcohol (e.g., amprenavir solution (Agenerase)), lithium, or macrolide immunosuppressants (e.g., tacrolimus (Prograf, Fujimycin)) because Metronidazole may increase their side effects