Pliva's Metoclopramide

Metoclopramide Effects and Usage

Metoclopramide - generic Reglan / Maxolon

What kind of medication is Metoclopramide?

Metoclopramide is a gastrointestinal stimulant and antinauseant used to treat gastroesophageal reflux disease (GERD) and certain digestive problem in diabetic patients. It relieves nausea, heartburn, a feeling of fullness after meals, and loss of appetite.

When distributed by Pliva Pharmaceuticals, Inc., Metoclopramide is available on the market as Pliva 517 5 mg and Pliva 430 10 mg pills.

The medication is also marketed under various trade names that include Reglan and Maxolon.

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What are possible side effects of using Metoclopramide?

Adverse reactions are rare, but they may include:

  • abdominal cramps
  • seizures
  • dark urine
  • difficulty in breathing or swallowing
  • headache
  • dizziness
  • fast or irregular heartbeat
  • increase in blood pressure
  • sweating
  • itching and skin rash
  • If overdosed, Metoclopramide may cause confusion or drowsiness.

    What is the recommended dose of Metoclopramide?

  • In adults, the dose is 10 to 15 mg up to four times a day. The medication is taken about half an hour before the expected symptoms begin.

  • In children, the dose must be determined by the physician.

  • When should Metoclopramide be avoided?

    Metoclopramide should not be used

  • in patients allergic to Metoclopramide
  • in epileptic patients
  • in patients suffering from bleeding, blockage, or perforation in the stomach or intestines
  • in patients suffering from tumors on your adrenal gland

  • Metoclopramide should be used with caution

  • by pregnant or breast-feeding women
  • by patients who have a history of mental or mood problems
  • by patients who have a history of asthma, heart failure, hypertension, diabetes, Parkinson disease, blood problems, kidney or liver problems, or breast cancer

  • Metoclopramide should not be be combined with:

  • phenothiazines (t.g., chlorpromazine (Thorazine, Largactil)) becasue they may cause abnormal, involuntary muscle movements of the head, neck, or limbs.

  • MAOIs (e.g., phenelzine (Nardil)) because of the increased risk of high blood pressure and seizures

  • hyoscyamine (Levsin) and other anticholinergic medicines because they may increase the effects of Metoclopramide

  • sedatives and narcotic pain relivers because their side effects can be dangerously increased by Metoclopramide

  • Cabergoline (Dostinex, Cabaser), digoxin (Lanoxin), or pergolide (Permax) because their effectiveness may be decreased by Metoclopramide